Five membered and two nitrogen hetetro atom containing heterocyclic compounds like Imidazole, Benzimidazole, Pyrazole, Oxadiazole, and Thiadiazole possess varieties of biological activity. These entire compounds collectively known as diazole. Many of literature reveal that among all diazole, imidazole and benzimidazole have wide and distinct antimicrobial activity. Benzimidazoles are remarkably effective compounds, extensive biochemical and pharmacological studies have confirmed that these molecules are effective against various strains of microorganisms. Various newer derivatives of benzmidazol and its Schiff’s base was prepared and screened for antibacterial and antifungal activity.
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